Drug interactions
Gemcitabine + Ublituximab
Severity: Moderate
Gemcitabine and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and gemcitabine causes myelosuppression, so combined use may increase infection risk. The effect is additive.
What this interaction means in plain words
Gemcitabine and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemcitabine belongs to Oncology; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from B-cell depletion and cytotoxic bone marrow suppression.
What to do
Monitor for infection and follow blood counts regularly. Consider the prolonged B-cell depletion when planning chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Other interactions of Ublituximab
Frequently asked questions
Can I take Gemcitabine with Ublituximab?
MediHelp rates the interaction as moderate. Gemcitabine and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells and gemcitabine causes myelosuppression, so combined use may increase infection risk. The effect is additive.
How serious is the interaction between Gemcitabine and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and follow blood counts regularly. Consider the prolonged B-cell depletion when planning chemotherapy.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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