Drug interactions
Gemfibrozil + Glecaprevir / pibrentasvir
Severity: Moderate
Gemfibrozil and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil inhibits hepatic uptake transporters that handle glecaprevir, so glecaprevir exposure may increase. This could raise the risk of adverse effects such as liver enzyme elevations.
What this interaction means in plain words
Gemfibrozil and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of glecaprevir by gemfibrozil.
What to do
Monitor liver function and tolerability during coadministration; consider an alternative lipid-lowering agent such as fenofibrate if concerns arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Gemfibrozil and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil inhibits hepatic uptake transporters that handle glecaprevir, so glecaprevir exposure may increase. This could raise the risk of adverse effects such as liver enzyme elevations.
How serious is the interaction between Gemfibrozil and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and tolerability during coadministration; consider an alternative lipid-lowering agent such as fenofibrate if concerns arise.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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