Drug interactions
Gemfibrozil + Insulin lispro
Severity: Minor
Gemfibrozil and Insulin lispro: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may modestly increase the glucose-lowering effect of insulin lispro, which could lead to hypoglycemia. The effect is typically small.
What this interaction means in plain words
Gemfibrozil and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gemfibrozil belongs to Cardiovascular; Insulin lispro belongs to Endocrine.
Why it happens
Additive glucose lowering, possibly through improved insulin sensitivity; no pharmacokinetic mechanism is established.
What to do
Monitor blood glucose when gemfibrozil is started or stopped. Reduce the lispro dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Insulin lispro
Frequently asked questions
Can I take Gemfibrozil with Insulin lispro?
MediHelp rates the interaction as minor. Gemfibrozil and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gemfibrozil may modestly increase the glucose-lowering effect of insulin lispro, which could lead to hypoglycemia. The effect is typically small.
How serious is the interaction between Gemfibrozil and Insulin lispro?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when gemfibrozil is started or stopped. Reduce the lispro dose if hypoglycemia occurs.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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