Drug interactions
Gemfibrozil + Insulin nph
Severity: Minor
Gemfibrozil and Insulin nph: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates such as gemfibrozil may improve insulin sensitivity and modestly lower glucose. In insulin-treated patients this can increase the risk of hypoglycemia.
What this interaction means in plain words
Gemfibrozil and Insulin nph have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive glucose-lowering pharmacodynamic effect from improved insulin sensitivity.
What to do
Monitor blood glucose after starting or stopping gemfibrozil and adjust insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Insulin nph?
MediHelp rates the interaction as minor. Gemfibrozil and Insulin nph have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fibrates such as gemfibrozil may improve insulin sensitivity and modestly lower glucose. In insulin-treated patients this can increase the risk of hypoglycemia.
How serious is the interaction between Gemfibrozil and Insulin nph?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping gemfibrozil and adjust insulin dose if hypoglycemia occurs.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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