Drug interactions
Gemfibrozil + Paclitaxel protein bound
Severity: Major
Gemfibrozil and Paclitaxel protein bound: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil and its glucuronide strongly inhibit CYP2C8, a main route of paclitaxel clearance. Paclitaxel exposure may rise, increasing myelosuppression and neuropathy risk.
What this interaction means in plain words
Gemfibrozil and Paclitaxel protein bound can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP2C8-mediated paclitaxel metabolism by gemfibrozil.
What to do
Avoid the combination where possible and use another lipid-lowering agent such as fenofibrate. If coadministered, monitor blood counts and neuropathy closely and reduce paclitaxel dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Paclitaxel protein bound?
MediHelp rates the interaction as major. Gemfibrozil and Paclitaxel protein bound can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil and its glucuronide strongly inhibit CYP2C8, a main route of paclitaxel clearance. Paclitaxel exposure may rise, increasing myelosuppression and neuropathy risk.
How serious is the interaction between Gemfibrozil and Paclitaxel protein bound?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use another lipid-lowering agent such as fenofibrate. If coadministered, monitor blood counts and neuropathy closely and reduce paclitaxel dose as needed.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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