Drug interactions
Gemfibrozil + Sulbactam / durlobactam
Severity: Minor
Gemfibrozil and Sulbactam / durlobactam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulbactam is eliminated partly by renal tubular secretion via organic anion transporters, which gemfibrozil can inhibit. Sulbactam levels might rise slightly, but sulbactam has a wide safety margin.
What this interaction means in plain words
Gemfibrozil and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OAT-mediated renal tubular secretion of sulbactam by gemfibrozil.
What to do
No dose change is generally needed. Monitor for beta-lactam adverse effects such as rash or diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Sulbactam / durlobactam?
MediHelp rates the interaction as minor. Gemfibrozil and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulbactam is eliminated partly by renal tubular secretion via organic anion transporters, which gemfibrozil can inhibit. Sulbactam levels might rise slightly, but sulbactam has a wide safety margin.
How serious is the interaction between Gemfibrozil and Sulbactam / durlobactam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for beta-lactam adverse effects such as rash or diarrhea.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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