Drug interactions
Gemifloxacin + Glasdegib
Severity: Major
Gemifloxacin and Glasdegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib has been associated with QT prolongation, as has gemifloxacin. Combined use may add to QTc prolongation and arrhythmia risk.
What this interaction means in plain words
Gemifloxacin and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemifloxacin belongs to Anti Bacterial; Glasdegib belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization.
What to do
Use an alternative antibiotic when possible. If both are needed, monitor ECG and electrolytes more frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Gemifloxacin with Glasdegib?
MediHelp rates the interaction as major. Gemifloxacin and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glasdegib has been associated with QT prolongation, as has gemifloxacin. Combined use may add to QTc prolongation and arrhythmia risk.
How serious is the interaction between Gemifloxacin and Glasdegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic when possible. If both are needed, monitor ECG and electrolytes more frequently.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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