Drug interactions
Gemifloxacin + Gliclazide
Severity: Moderate
Gemifloxacin and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking sulfonylureas. Severe hypoglycemia, sometimes with coma, has been reported, with higher risk in the elderly and those with renal impairment.
What this interaction means in plain words
Gemifloxacin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Gliclazide belongs to Endocrine.
Why it happens
Quinolones block pancreatic potassium channels and stimulate insulin release, adding to the sulfonylurea effect.
What to do
Monitor blood glucose closely during the antibiotic course and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Gliclazide?
MediHelp rates the interaction as moderate. Gemifloxacin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking sulfonylureas. Severe hypoglycemia, sometimes with coma, has been reported, with higher risk in the elderly and those with renal impairment.
How serious is the interaction between Gemifloxacin and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if dysglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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