Drug interactions
Gemifloxacin + Glipizide-metformin
Severity: Moderate
Gemifloxacin and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients on antidiabetic drugs. Severe hypoglycemia has been reported, mainly in older patients and those on sulfonylureas.
What this interaction means in plain words
Gemifloxacin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Glipizide-metformin belongs to Endocrine.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, producing dysglycemia that adds to the effect of sulfonylureas.
What to do
Monitor blood glucose during fluoroquinolone therapy and educate the patient on symptoms of hypo- and hyperglycemia. Stop the fluoroquinolone and treat if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gemifloxacin and Glipizide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Glipizide-metformin?
MediHelp rates the interaction as moderate. Gemifloxacin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients on antidiabetic drugs. Severe hypoglycemia has been reported, mainly in older patients and those on sulfonylureas.
How serious is the interaction between Gemifloxacin and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during fluoroquinolone therapy and educate the patient on symptoms of hypo- and hyperglycemia. Stop the fluoroquinolone and treat if significant dysglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
