Drug interactions
Gemifloxacin + Glyburide-metformin
Severity: Moderate
Gemifloxacin and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients on antidiabetic drugs, with sulfonylureas posing the greatest hypoglycemia risk. Severe cases have occurred, particularly in older adults and those with renal impairment.
What this interaction means in plain words
Gemifloxacin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Glyburide-metformin belongs to Endocrine.
Why it happens
Fluoroquinolone effects on pancreatic beta-cell insulin release, producing additive hypoglycemia with sulfonylureas.
What to do
Monitor blood glucose during fluoroquinolone therapy and teach patients to recognize hypoglycemia. Stop the antibiotic and treat if significant glucose disturbance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Glyburide-metformin?
MediHelp rates the interaction as moderate. Gemifloxacin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients on antidiabetic drugs, with sulfonylureas posing the greatest hypoglycemia risk. Severe cases have occurred, particularly in older adults and those with renal impairment.
How serious is the interaction between Gemifloxacin and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during fluoroquinolone therapy and teach patients to recognize hypoglycemia. Stop the antibiotic and treat if significant glucose disturbance occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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