Drug interactions
Gemifloxacin + Ibuprofen
Severity: Moderate
Gemifloxacin and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may add to the seizure-provoking potential of fluoroquinolones such as gemifloxacin. Convulsions are rare but reported, and risk is higher with predisposing conditions.
What this interaction means in plain words
Gemifloxacin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Ibuprofen belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors may be potentiated by NSAIDs; the exact mechanism is not established.
What to do
Avoid the combination in patients with epilepsy or a history of seizures. Otherwise use the lowest effective doses and monitor for neurological symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Ibuprofen?
MediHelp rates the interaction as moderate. Gemifloxacin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may add to the seizure-provoking potential of fluoroquinolones such as gemifloxacin. Convulsions are rare but reported, and risk is higher with predisposing conditions.
How serious is the interaction between Gemifloxacin and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with epilepsy or a history of seizures. Otherwise use the lowest effective doses and monitor for neurological symptoms.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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