Drug interactions
Gemifloxacin + Insulin glargine-lixisenatide
Severity: Moderate
Gemifloxacin and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in diabetic patients, particularly those on insulin or insulin secretagogues. Severe hypoglycemia, including coma, has been reported, with the elderly and those with renal impairment at greater risk.
What this interaction means in plain words
Gemifloxacin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Fluoroquinolone-induced pancreatic beta-cell insulin release and dysglycemia, adding to the effects of the antidiabetic drugs.
What to do
Monitor blood glucose closely during the antibiotic course and educate the patient on hypoglycemia symptoms. Stop the fluoroquinolone and switch to another class if dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Gemifloxacin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in diabetic patients, particularly those on insulin or insulin secretagogues. Severe hypoglycemia, including coma, has been reported, with the elderly and those with renal impairment at greater risk.
How serious is the interaction between Gemifloxacin and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and educate the patient on hypoglycemia symptoms. Stop the fluoroquinolone and switch to another class if dysglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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