Drug interactions
Gemifloxacin + Meclofenamic acid
Severity: Moderate
Gemifloxacin and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones lower seizure threshold, and NSAIDs may potentiate this effect in some patients. The risk of CNS stimulation or seizures is higher with predisposing factors.
What this interaction means in plain words
Gemifloxacin and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors that is potentiated by NSAIDs; the mechanism is not fully established.
What to do
Avoid the combination in patients with epilepsy, prior seizures or CNS disease, and consider another antibiotic or analgesic. Counsel patients to report tremor, confusion or seizure activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Meclofenamic acid?
MediHelp rates the interaction as moderate. Gemifloxacin and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones lower seizure threshold, and NSAIDs may potentiate this effect in some patients. The risk of CNS stimulation or seizures is higher with predisposing factors.
How serious is the interaction between Gemifloxacin and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with epilepsy, prior seizures or CNS disease, and consider another antibiotic or analgesic. Counsel patients to report tremor, confusion or seizure activity.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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