Drug interactions
Gemifloxacin + Metformin-repaglinide
Severity: Moderate
Gemifloxacin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs. Severe hypoglycemia has been reported, particularly in older patients and those with renal impairment.
What this interaction means in plain words
Gemifloxacin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Metformin-repaglinide belongs to Endocrine.
Why it happens
Fluoroquinolone effects on pancreatic beta-cell insulin release causing dysglycemia.
What to do
Counsel patients on symptoms of hypoglycemia and monitor blood glucose during the antibiotic course. Consider an alternative antibiotic if glucose becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Gemifloxacin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs. Severe hypoglycemia has been reported, particularly in older patients and those with renal impairment.
How serious is the interaction between Gemifloxacin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on symptoms of hypoglycemia and monitor blood glucose during the antibiotic course. Consider an alternative antibiotic if glucose becomes unstable.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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