Drug interactions
Gemifloxacin + Naproxen
Severity: Moderate
Gemifloxacin and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent NSAID and fluoroquinolone use may lower the seizure threshold and cause CNS stimulation. Seizures are uncommon, but the risk is greater in patients with epilepsy, prior CNS disease, renal impairment or high fluoroquinolone exposure.
What this interaction means in plain words
Gemifloxacin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Naproxen belongs to Musculoskeletal.
Why it happens
Fluoroquinolones antagonize GABA-A receptors, and NSAIDs may potentiate this effect; the mechanism is incompletely characterized.
What to do
Avoid the combination in patients with seizure disorders or other CNS risk factors, or choose a different antibiotic. Otherwise counsel patients to report tremor, confusion or seizure activity and adjust the fluoroquinolone dose for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Naproxen?
MediHelp rates the interaction as moderate. Gemifloxacin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent NSAID and fluoroquinolone use may lower the seizure threshold and cause CNS stimulation. Seizures are uncommon, but the risk is greater in patients with epilepsy, prior CNS disease, renal impairment or high fluoroquinolone exposure.
How serious is the interaction between Gemifloxacin and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders or other CNS risk factors, or choose a different antibiotic. Otherwise counsel patients to report tremor, confusion or seizure activity and adjust the fluoroquinolone dose for renal function.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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