Drug interactions
Gemifloxacin + Nortriptyline
Severity: Moderate
Gemifloxacin and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so together they may raise the risk of ventricular arrhythmia including torsades de pointes. The risk is higher with electrolyte disturbance, heart disease or higher nortriptyline levels.
What this interaction means in plain words
Gemifloxacin and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac potassium channel blockade.
What to do
Check a baseline ECG and correct hypokalemia and hypomagnesemia. Consider an alternative antibiotic in patients with a long QTc or other arrhythmia risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Nortriptyline?
MediHelp rates the interaction as moderate. Gemifloxacin and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so together they may raise the risk of ventricular arrhythmia including torsades de pointes. The risk is higher with electrolyte disturbance, heart disease or higher nortriptyline levels.
How serious is the interaction between Gemifloxacin and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct hypokalemia and hypomagnesemia. Consider an alternative antibiotic in patients with a long QTc or other arrhythmia risk factors.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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