Drug interactions
Gemifloxacin + Prednisolone
Severity: Major
Gemifloxacin and Prednisolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and fluoroquinolone use increases the risk of tendinopathy and tendon rupture, notably of the Achilles tendon. The risk is greater in older patients, those on higher steroid doses and transplant recipients.
What this interaction means in plain words
Gemifloxacin and Prednisolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemifloxacin belongs to Anti Bacterial; Prednisolone belongs to Endocrine.
Why it happens
Both drugs have adverse effects on tendon collagen and tenocytes, producing additive tendon toxicity.
What to do
Avoid the combination where an alternative antibiotic is suitable, especially in older patients. If used, stop gemifloxacin and rest the limb at the first sign of tendon pain.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Prednisolone?
MediHelp rates the interaction as major. Gemifloxacin and Prednisolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent corticosteroid and fluoroquinolone use increases the risk of tendinopathy and tendon rupture, notably of the Achilles tendon. The risk is greater in older patients, those on higher steroid doses and transplant recipients.
How serious is the interaction between Gemifloxacin and Prednisolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antibiotic is suitable, especially in older patients. If used, stop gemifloxacin and rest the limb at the first sign of tendon pain.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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