Drug interactions
Gemifloxacin + Selpercatinib
Severity: Moderate
Gemifloxacin and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may add to the risk of serious ventricular arrhythmias, including torsades de pointes. The risk is higher with electrolyte disturbances, bradycardia or underlying heart disease.
What this interaction means in plain words
Gemifloxacin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Selpercatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac potassium channel (hERG) effects.
What to do
Obtain a baseline ECG and check potassium and magnesium, correcting any deficits. Repeat the ECG during treatment, or choose a non-QT-prolonging antibiotic if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Gemifloxacin with Selpercatinib?
MediHelp rates the interaction as moderate. Gemifloxacin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so using them together may add to the risk of serious ventricular arrhythmias, including torsades de pointes. The risk is higher with electrolyte disturbances, bradycardia or underlying heart disease.
How serious is the interaction between Gemifloxacin and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and check potassium and magnesium, correcting any deficits. Repeat the ECG during treatment, or choose a non-QT-prolonging antibiotic if the QTc becomes prolonged.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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