Drug interactions
Gemifloxacin + Tretinoin
Severity: Moderate
Gemifloxacin and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause photosensitivity, and tretinoin, particularly topical use, increases skin sensitivity to light. Combined use may lead to more severe sunburn-like reactions. Oral tretinoin also carries other risks such as raised intracranial pressure, which quinolones may also contribute to.
What this interaction means in plain words
Gemifloxacin and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Tretinoin belongs to Dermatology.
Why it happens
Additive phototoxic effects on the skin from two photosensitizing drugs.
What to do
Advise strict sun protection and avoidance of UV exposure while both are used. Consider an alternative antibiotic if photosensitivity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Gemifloxacin with Tretinoin?
MediHelp rates the interaction as moderate. Gemifloxacin and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause photosensitivity, and tretinoin, particularly topical use, increases skin sensitivity to light. Combined use may lead to more severe sunburn-like reactions. Oral tretinoin also carries other risks such as raised intracranial pressure, which quinolones may also contribute to.
How serious is the interaction between Gemifloxacin and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict sun protection and avoidance of UV exposure while both are used. Consider an alternative antibiotic if photosensitivity develops.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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