Drug interactions
Gemtuzumab + Goserelin
Severity: Moderate
Gemtuzumab and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin has been associated with QT prolongation, and goserelin may add to it. The combination may increase arrhythmia risk in patients with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Gemtuzumab and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and monitor it with electrolytes during treatment. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Frequently asked questions
Can I take Gemtuzumab with Goserelin?
MediHelp rates the interaction as moderate. Gemtuzumab and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin has been associated with QT prolongation, and goserelin may add to it. The combination may increase arrhythmia risk in patients with electrolyte disturbance or cardiac disease.
How serious is the interaction between Gemtuzumab and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it with electrolytes during treatment. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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