Drug interactions
Gemtuzumab + Mirtazapine
Severity: Moderate
Gemtuzumab and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin carries a QT prolongation warning, and mirtazapine can also prolong the QT interval in some circumstances. Used together, they may add to arrhythmia risk in vulnerable patients.
What this interaction means in plain words
Gemtuzumab and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation.
What to do
Obtain an ECG and check electrolytes before and during treatment in patients with other QT risk factors. Correct potassium and magnesium abnormalities and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Mirtazapine?
MediHelp rates the interaction as moderate. Gemtuzumab and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin carries a QT prolongation warning, and mirtazapine can also prolong the QT interval in some circumstances. Used together, they may add to arrhythmia risk in vulnerable patients.
How serious is the interaction between Gemtuzumab and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check electrolytes before and during treatment in patients with other QT risk factors. Correct potassium and magnesium abnormalities and review other QT-prolonging drugs.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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