Drug interactions
Gentamicin + Hydrochlorothiazide-telmisartan
Severity: Moderate
Gentamicin and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin is nephrotoxic, and volume depletion from the thiazide plus ARB-mediated reduction in glomerular pressure can increase the risk of acute kidney injury. Diuretics may also add to aminoglycoside-related electrolyte disturbances such as hypokalemia and hypomagnesemia.
What this interaction means in plain words
Gentamicin and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Reduced renal perfusion and volume depletion increase aminoglycoside accumulation and tubular toxicity, with additive renal electrolyte wasting.
What to do
Monitor creatinine, gentamicin levels, potassium and magnesium, and keep the patient well hydrated. Consider temporarily withholding the ARB-diuretic product during acute illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gentamicin and Hydrochlorothiazide-telmisartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Gentamicin and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gentamicin is nephrotoxic, and volume depletion from the thiazide plus ARB-mediated reduction in glomerular pressure can increase the risk of acute kidney injury. Diuretics may also add to aminoglycoside-related electrolyte disturbances such as hypokalemia and hypomagnesemia.
How serious is the interaction between Gentamicin and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, gentamicin levels, potassium and magnesium, and keep the patient well hydrated. Consider temporarily withholding the ARB-diuretic product during acute illness.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
