Drug interactions
Gentamicin + Meloxicam
Severity: Moderate
Gentamicin and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of aminoglycosides and add to nephrotoxicity. This can raise gentamicin levels, particularly in neonates, the elderly and dehydrated patients.
What this interaction means in plain words
Gentamicin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Meloxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and glomerular filtration, decreasing aminoglycoside clearance and compounding nephrotoxicity.
What to do
Monitor serum creatinine and gentamicin trough levels and keep patients well hydrated. Avoid meloxicam where possible during aminoglycoside therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Meloxicam?
MediHelp rates the interaction as moderate. Gentamicin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal clearance of aminoglycosides and add to nephrotoxicity. This can raise gentamicin levels, particularly in neonates, the elderly and dehydrated patients.
How serious is the interaction between Gentamicin and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels and keep patients well hydrated. Avoid meloxicam where possible during aminoglycoside therapy.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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