Drug interactions
Gentamicin + Sacubitril-valsartan
Severity: Moderate
Gentamicin and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin is nephrotoxic and can cause renal potassium and magnesium wasting, while sacubitril-valsartan reduces glomerular filtration pressure and can raise potassium. Combined use may increase the risk of acute kidney injury and electrolyte disturbance.
What this interaction means in plain words
Gentamicin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive renal hemodynamic compromise from angiotensin receptor blockade with aminoglycoside tubular toxicity, and opposing electrolyte effects.
What to do
Monitor serum creatinine, potassium and magnesium during gentamicin therapy, and check aminoglycoside levels. Consider holding sacubitril-valsartan if renal function deteriorates or the patient becomes volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gentamicin and Sacubitril-valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Gentamicin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gentamicin is nephrotoxic and can cause renal potassium and magnesium wasting, while sacubitril-valsartan reduces glomerular filtration pressure and can raise potassium. Combined use may increase the risk of acute kidney injury and electrolyte disturbance.
How serious is the interaction between Gentamicin and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium during gentamicin therapy, and check aminoglycoside levels. Consider holding sacubitril-valsartan if renal function deteriorates or the patient becomes volume depleted.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
