Drug interactions
Gentamicin + Streptomycin
Severity: Major
Gentamicin and Streptomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two aminoglycosides increases the risk of nephrotoxicity, ototoxicity (cochlear and vestibular), and neuromuscular blockade. The toxicities are additive without any added benefit in most settings.
What this interaction means in plain words
Gentamicin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gentamicin belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive renal tubular accumulation, inner ear hair cell toxicity and neuromuscular blockade.
What to do
Avoid concurrent use of two systemic aminoglycosides. If unavoidable, monitor renal function, drug levels, hearing and vestibular function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Streptomycin?
MediHelp rates the interaction as major. Gentamicin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two aminoglycosides increases the risk of nephrotoxicity, ototoxicity (cochlear and vestibular), and neuromuscular blockade. The toxicities are additive without any added benefit in most settings.
How serious is the interaction between Gentamicin and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two systemic aminoglycosides. If unavoidable, monitor renal function, drug levels, hearing and vestibular function closely.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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