Drug interactions
Gepirone + Isoniazid
Severity: Moderate
Gepirone and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is metabolized by CYP3A4 and labeling requires dose limits with CYP3A4 inhibitors. Isoniazid is a weak CYP3A4 inhibitor, and its weak MAO-inhibiting effect also raises a theoretical serotonergic concern.
What this interaction means in plain words
Gepirone and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid and weak MAO inhibition adding to serotonergic effects.
What to do
Monitor for dizziness, sedation, QT-related symptoms and serotonin syndrome features. Consider a lower gepirone dose if exposure effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Isoniazid?
MediHelp rates the interaction as moderate. Gepirone and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone is metabolized by CYP3A4 and labeling requires dose limits with CYP3A4 inhibitors. Isoniazid is a weak CYP3A4 inhibitor, and its weak MAO-inhibiting effect also raises a theoretical serotonergic concern.
How serious is the interaction between Gepirone and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, sedation, QT-related symptoms and serotonin syndrome features. Consider a lower gepirone dose if exposure effects appear.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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