Drug interactions
Gepirone + Lithium
Severity: Moderate
Gepirone and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a serotonin 5-HT1A agonist antidepressant and lithium enhances serotonergic function. Combined use may increase the risk of serotonin syndrome. Gepirone may also prolong the QT interval.
What this interaction means in plain words
Gepirone and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Lithium belongs to Central Nervous System.
Why it happens
Additive serotonergic activity, with possible additive QT effects.
What to do
Monitor for features of serotonin syndrome, especially after dose increases, and stop the serotonergic agent if it occurs. Consider an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Lithium?
MediHelp rates the interaction as moderate. Gepirone and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone is a serotonin 5-HT1A agonist antidepressant and lithium enhances serotonergic function. Combined use may increase the risk of serotonin syndrome. Gepirone may also prolong the QT interval.
How serious is the interaction between Gepirone and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin syndrome, especially after dose increases, and stop the serotonergic agent if it occurs. Consider an ECG if other QT risk factors are present.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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