Drug interactions
Gepirone + Metronidazole
Severity: Moderate
Gepirone and Metronidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may raise gepirone exposure via CYP3A4 inhibition, increasing dizziness, sedation and QT prolongation risk.
What this interaction means in plain words
Gepirone and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Metronidazole belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition by metronidazole reduces gepirone clearance.
What to do
Reduce the gepirone dose by about half per labeling when a moderate CYP3A4 inhibitor is used. Monitor for dizziness and QT-related symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Metronidazole?
MediHelp rates the interaction as moderate. Gepirone and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metronidazole may raise gepirone exposure via CYP3A4 inhibition, increasing dizziness, sedation and QT prolongation risk.
How serious is the interaction between Gepirone and Metronidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the gepirone dose by about half per labeling when a moderate CYP3A4 inhibitor is used. Monitor for dizziness and QT-related symptoms.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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