Drug interactions
Gepirone + Olanzapine
Severity: Moderate
Gepirone and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone carries a QT prolongation warning, and olanzapine can also modestly prolong the QT interval. Together they may increase the risk of ventricular arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Gepirone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Check an ECG at baseline and when the dose changes, and correct electrolyte abnormalities. Avoid the combination in patients with congenital long QT syndrome or other significant QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Olanzapine?
MediHelp rates the interaction as moderate. Gepirone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone carries a QT prolongation warning, and olanzapine can also modestly prolong the QT interval. Together they may increase the risk of ventricular arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Gepirone and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG at baseline and when the dose changes, and correct electrolyte abnormalities. Avoid the combination in patients with congenital long QT syndrome or other significant QT risk.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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