Drug interactions
Gilteritinib + Lofexidine
Severity: Major
Gilteritinib and Lofexidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so combined use raises the potential for serious ventricular arrhythmia including torsades de pointes. Lofexidine-induced bradycardia may add to the risk.
What this interaction means in plain words
Gilteritinib and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Lofexidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid combining where an alternative exists; otherwise obtain ECGs at baseline and periodically and keep potassium and magnesium normal. Reduce or hold a drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Lofexidine?
MediHelp rates the interaction as major. Gilteritinib and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so combined use raises the potential for serious ventricular arrhythmia including torsades de pointes. Lofexidine-induced bradycardia may add to the risk.
How serious is the interaction between Gilteritinib and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists; otherwise obtain ECGs at baseline and periodically and keep potassium and magnesium normal. Reduce or hold a drug if QTc becomes markedly prolonged.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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