Drug interactions
Gilteritinib + Paroxetine
Severity: Major
Gilteritinib and Paroxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib can prolong the QT interval and paroxetine may add to this effect, raising the risk of arrhythmia. Gilteritinib's activity may also be reduced by drugs that target 5-HT2B or sigma receptors, although the clinical effect with paroxetine is uncertain.
What this interaction means in plain words
Gilteritinib and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Paroxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; possible pharmacodynamic antagonism at receptors involved in gilteritinib activity.
What to do
Obtain an ECG before starting and during treatment, and correct potassium and magnesium. Consider an alternative antidepressant with lower QT liability if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Paroxetine?
MediHelp rates the interaction as major. Gilteritinib and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib can prolong the QT interval and paroxetine may add to this effect, raising the risk of arrhythmia. Gilteritinib's activity may also be reduced by drugs that target 5-HT2B or sigma receptors, although the clinical effect with paroxetine is uncertain.
How serious is the interaction between Gilteritinib and Paroxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting and during treatment, and correct potassium and magnesium. Consider an alternative antidepressant with lower QT liability if feasible.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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