Drug interactions
Gilteritinib + Pazopanib
Severity: Major
Gilteritinib and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may raise the risk of torsades de pointes and other serious ventricular arrhythmias. Risk is higher with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Gilteritinib and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization effects.
What to do
Avoid the combination if possible. If needed, obtain baseline and periodic ECGs, correct potassium and magnesium, and reduce or stop therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Pazopanib?
MediHelp rates the interaction as major. Gilteritinib and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, so combined use may raise the risk of torsades de pointes and other serious ventricular arrhythmias. Risk is higher with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Gilteritinib and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If needed, obtain baseline and periodic ECGs, correct potassium and magnesium, and reduce or stop therapy if QTc becomes markedly prolonged.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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