Drug interactions
Gilteritinib + Telavancin
Severity: Major
Gilteritinib and Telavancin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval and telavancin may do the same. Combining them increases the risk of torsades de pointes, particularly with electrolyte abnormalities.
What this interaction means in plain words
Gilteritinib and Telavancin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Telavancin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation.
What to do
Prefer a non-QT-prolonging antibacterial where possible. If combined, check ECG and correct potassium and magnesium, and reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Telavancin?
MediHelp rates the interaction as major. Gilteritinib and Telavancin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib prolongs the QT interval and telavancin may do the same. Combining them increases the risk of torsades de pointes, particularly with electrolyte abnormalities.
How serious is the interaction between Gilteritinib and Telavancin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antibacterial where possible. If combined, check ECG and correct potassium and magnesium, and reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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