Drug interactions
Gilteritinib + Triptorelin
Severity: Moderate
Gilteritinib and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib has a labeled risk of QT prolongation, and triptorelin may add to it. The combination could increase risk of torsades de pointes, especially with electrolyte disturbance.
What this interaction means in plain words
Gilteritinib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Triptorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain ECG before starting, on days 8 and 15 of cycle 1, and monthly thereafter, correcting electrolytes. Reduce or interrupt gilteritinib if QTc exceeds 500 ms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Triptorelin?
MediHelp rates the interaction as moderate. Gilteritinib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib has a labeled risk of QT prolongation, and triptorelin may add to it. The combination could increase risk of torsades de pointes, especially with electrolyte disturbance.
How serious is the interaction between Gilteritinib and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG before starting, on days 8 and 15 of cycle 1, and monthly thereafter, correcting electrolytes. Reduce or interrupt gilteritinib if QTc exceeds 500 ms.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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