Drug interactions
Givinostat + Indacaterol-glycopyrronium
Severity: Moderate
Givinostat and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and indacaterol may add proarrhythmic effects through beta-agonism and potassium lowering. The combination raises the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Givinostat and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarisation.
What to do
Obtain ECGs at initiation, during concomitant use and when clinically indicated, and correct potassium and magnesium. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Givinostat and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval, and indacaterol may add proarrhythmic effects through beta-agonism and potassium lowering. The combination raises the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Givinostat and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation, during concomitant use and when clinically indicated, and correct potassium and magnesium. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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