Drug interactions
Givinostat + Midazolam
Severity: Minor
Givinostat and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak CYP3A4 inhibitor and may modestly raise midazolam levels. The increase is usually small but could prolong sedation, especially with oral midazolam.
What this interaction means in plain words
Givinostat and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 reduces midazolam metabolism.
What to do
Monitor for prolonged sedation, particularly with oral midazolam, and lower the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Midazolam?
MediHelp rates the interaction as minor. Givinostat and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak CYP3A4 inhibitor and may modestly raise midazolam levels. The increase is usually small but could prolong sedation, especially with oral midazolam.
How serious is the interaction between Givinostat and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prolonged sedation, particularly with oral midazolam, and lower the dose if needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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