Drug interactions
Givinostat + Sirolimus
Severity: Minor
Givinostat and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak CYP3A4 inhibitor and may modestly increase sirolimus concentrations. Because sirolimus has a narrow therapeutic index, even a small increase may matter.
What this interaction means in plain words
Givinostat and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
Weak CYP3A4 inhibition by givinostat reduces sirolimus metabolism.
What to do
Check sirolimus trough concentrations after starting or stopping givinostat and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Sirolimus?
MediHelp rates the interaction as minor. Givinostat and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak CYP3A4 inhibitor and may modestly increase sirolimus concentrations. Because sirolimus has a narrow therapeutic index, even a small increase may matter.
How serious is the interaction between Givinostat and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sirolimus trough concentrations after starting or stopping givinostat and adjust the dose if needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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