Drug interactions
Glasdegib + Indacaterol-glycopyrronium
Severity: Moderate
Glasdegib and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval, and beta-agonists such as indacaterol may add to repolarization risk. Together they may increase the likelihood of ventricular arrhythmia, especially with electrolyte imbalance.
What this interaction means in plain words
Glasdegib and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glasdegib belongs to Oncology; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-related hypokalemia as a possible contributor.
What to do
Obtain ECG and electrolytes at baseline and periodically during treatment, correcting potassium and magnesium. Consider an alternative bronchodilator if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Glasdegib and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval, and beta-agonists such as indacaterol may add to repolarization risk. Together they may increase the likelihood of ventricular arrhythmia, especially with electrolyte imbalance.
How serious is the interaction between Glasdegib and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and electrolytes at baseline and periodically during treatment, correcting potassium and magnesium. Consider an alternative bronchodilator if QTc lengthens significantly.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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