Drug interactions
Glasdegib + Itraconazole
Severity: Major
Glasdegib and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and itraconazole also raises glasdegib exposure through CYP3A4 inhibition. The combination increases the risk of torsades de pointes and other serious ventricular arrhythmias.
What this interaction means in plain words
Glasdegib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glasdegib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, plus itraconazole inhibition of CYP3A4-mediated glasdegib metabolism.
What to do
Use an alternative antifungal where possible. If the combination is unavoidable, obtain a baseline ECG, monitor ECG and electrolytes, and consider reducing the glasdegib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Itraconazole?
MediHelp rates the interaction as major. Glasdegib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and itraconazole also raises glasdegib exposure through CYP3A4 inhibition. The combination increases the risk of torsades de pointes and other serious ventricular arrhythmias.
How serious is the interaction between Glasdegib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antifungal where possible. If the combination is unavoidable, obtain a baseline ECG, monitor ECG and electrolytes, and consider reducing the glasdegib dose.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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