Drug interactions
Glasdegib + Solifenacin
Severity: Moderate
Glasdegib and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval, and solifenacin has a dose-related QT effect. The combination may raise arrhythmia risk, especially with electrolyte abnormalities.
What this interaction means in plain words
Glasdegib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glasdegib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium. Consider an alternative bladder agent if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Solifenacin?
MediHelp rates the interaction as moderate. Glasdegib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval, and solifenacin has a dose-related QT effect. The combination may raise arrhythmia risk, especially with electrolyte abnormalities.
How serious is the interaction between Glasdegib and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium. Consider an alternative bladder agent if the QTc lengthens.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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