Drug interactions
Glasdegib + Voriconazole
Severity: Major
Glasdegib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises glasdegib exposure via CYP3A4 inhibition, and both drugs can prolong the QT interval. Together this increases the risk of torsades de pointes and other glasdegib adverse effects.
What this interaction means in plain words
Glasdegib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glasdegib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition increases glasdegib levels, with additive QT prolongation.
What to do
Consider an alternative antifungal. If unavoidable, monitor ECG and electrolytes more frequently and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Voriconazole?
MediHelp rates the interaction as major. Glasdegib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole raises glasdegib exposure via CYP3A4 inhibition, and both drugs can prolong the QT interval. Together this increases the risk of torsades de pointes and other glasdegib adverse effects.
How serious is the interaction between Glasdegib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antifungal. If unavoidable, monitor ECG and electrolytes more frequently and correct hypokalemia and hypomagnesemia.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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