Drug interactions
Glecaprevir / pibrentasvir + Methylprednisolone
Severity: Minor
Glecaprevir / pibrentasvir and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may modestly increase methylprednisolone exposure. The clinical effect is likely small and short-lived during the hepatitis C treatment course.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-glycoprotein increases the absorption of methylprednisolone.
What to do
No dose adjustment is usually needed; monitor for increased steroid adverse effects with high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Methylprednisolone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may modestly increase methylprednisolone exposure. The clinical effect is likely small and short-lived during the hepatitis C treatment course.
How serious is the interaction between Glecaprevir / pibrentasvir and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for increased steroid adverse effects with high doses.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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