Drug interactions
Glecaprevir / pibrentasvir + Nevirapine
Severity: Major
Glecaprevir / pibrentasvir and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower glecaprevir and pibrentasvir concentrations and risk hepatitis C treatment failure. Labeling advises against coadministration with strong inducers, and nevirapine is a moderate inducer.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nevirapine induces CYP3A4 and possibly P-gp, lowering exposure to both agents.
What to do
Avoid the combination where possible and use an alternative antiretroviral such as an integrase inhibitor.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Nevirapine?
MediHelp rates the interaction as major. Glecaprevir / pibrentasvir and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine may lower glecaprevir and pibrentasvir concentrations and risk hepatitis C treatment failure. Labeling advises against coadministration with strong inducers, and nevirapine is a moderate inducer.
How serious is the interaction between Glecaprevir / pibrentasvir and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antiretroviral such as an integrase inhibitor.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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