Drug interactions
Glecaprevir / pibrentasvir + Ranolazine
Severity: Moderate
Glecaprevir / pibrentasvir and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ranolazine and glecaprevir/pibrentasvir can inhibit P-gp, and each is a P-gp substrate to some extent. Exposure to either may increase modestly, with greater ranolazine-related dizziness, nausea or QT effects possible.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual inhibition of P-glycoprotein efflux transport.
What to do
Monitor for ranolazine adverse effects such as dizziness and QTc prolongation. Reduce the ranolazine dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Ranolazine?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ranolazine and glecaprevir/pibrentasvir can inhibit P-gp, and each is a P-gp substrate to some extent. Exposure to either may increase modestly, with greater ranolazine-related dizziness, nausea or QT effects possible.
How serious is the interaction between Glecaprevir / pibrentasvir and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ranolazine adverse effects such as dizziness and QTc prolongation. Reduce the ranolazine dose if these occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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