Drug interactions
Glecaprevir / pibrentasvir + Risperidone
Severity: Minor
Glecaprevir / pibrentasvir and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, which may raise risperidone exposure modestly. This could increase dose-related adverse effects such as sedation, orthostatic hypotension and extrapyramidal symptoms.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-glycoprotein efflux, increasing risperidone absorption and exposure.
What to do
Monitor for sedation, hypotension and extrapyramidal symptoms during the antiviral course. Reduce the risperidone dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Risperidone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein, which may raise risperidone exposure modestly. This could increase dose-related adverse effects such as sedation, orthostatic hypotension and extrapyramidal symptoms.
How serious is the interaction between Glecaprevir / pibrentasvir and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and extrapyramidal symptoms during the antiviral course. Reduce the risperidone dose if adverse effects emerge.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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