Drug interactions
Glecaprevir / pibrentasvir + Temsirolimus
Severity: Moderate
Glecaprevir / pibrentasvir and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase temsirolimus exposure. This may raise the risk of mTOR-related adverse effects.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition reducing efflux of temsirolimus.
What to do
Monitor for temsirolimus toxicity during the short hepatitis C treatment course. Reduce the dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Temsirolimus?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase temsirolimus exposure. This may raise the risk of mTOR-related adverse effects.
How serious is the interaction between Glecaprevir / pibrentasvir and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity during the short hepatitis C treatment course. Reduce the dose if adverse effects occur.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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