Drug interactions
Glibenclamide + Pretomanid
Severity: Minor
Glibenclamide and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits BCRP in vitro, and glyburide is a BCRP substrate, so glyburide exposure may be modestly increased. Clinical significance is uncertain but hypoglycemia is possible.
What this interaction means in plain words
Glibenclamide and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glibenclamide belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
Why it happens
Possible inhibition of BCRP-mediated glyburide efflux by pretomanid.
What to do
Monitor blood glucose when pretomanid is started and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Glibenclamide with Pretomanid?
MediHelp rates the interaction as minor. Glibenclamide and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits BCRP in vitro, and glyburide is a BCRP substrate, so glyburide exposure may be modestly increased. Clinical significance is uncertain but hypoglycemia is possible.
How serious is the interaction between Glibenclamide and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when pretomanid is started and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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