Drug interactions
Gliclazide + Iloperidone
Severity: Moderate
Gliclazide and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and weight gain, which may worsen diabetes control. Gliclazide may need adjustment to maintain targets.
What this interaction means in plain words
Gliclazide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotics may induce insulin resistance and impair insulin secretion, opposing antidiabetic therapy.
What to do
Monitor blood glucose and HbA1c after starting iloperidone and intensify antidiabetic treatment if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Gliclazide with Iloperidone?
MediHelp rates the interaction as moderate. Gliclazide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can cause hyperglycemia and weight gain, which may worsen diabetes control. Gliclazide may need adjustment to maintain targets.
How serious is the interaction between Gliclazide and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting iloperidone and intensify antidiabetic treatment if needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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