Drug interactions
Gliclazide + Liraglutide
Severity: Moderate
Gliclazide and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide added to a sulfonylurea increases the risk of hypoglycemia, which can be severe. Liraglutide's effect is glucose-dependent, but gliclazide continues to stimulate insulin release regardless of glucose level.
What this interaction means in plain words
Gliclazide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive stimulation of insulin secretion by GLP-1 receptor agonism and sulfonylurea action.
What to do
Consider lowering the gliclazide dose when liraglutide is started. Monitor blood glucose and counsel on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gliclazide and Liraglutide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Liraglutide
Frequently asked questions
Can I take Gliclazide with Liraglutide?
MediHelp rates the interaction as moderate. Gliclazide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide added to a sulfonylurea increases the risk of hypoglycemia, which can be severe. Liraglutide's effect is glucose-dependent, but gliclazide continues to stimulate insulin release regardless of glucose level.
How serious is the interaction between Gliclazide and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the gliclazide dose when liraglutide is started. Monitor blood glucose and counsel on hypoglycemia symptoms.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
