Drug interactions
Gliclazide + Lornoxicam
Severity: Moderate
Gliclazide and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. Lornoxicam is a CYP2C9 substrate, as is gliclazide, so metabolic competition is possible, and renal effects of NSAIDs may add to the risk.
What this interaction means in plain words
Gliclazide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Possible competition for CYP2C9 metabolism and displacement from protein binding, with additional prostaglandin-mediated effects on insulin secretion; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping lornoxicam and reduce the gliclazide dose if hypoglycemia occurs. Keep NSAID courses short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Lornoxicam
Frequently asked questions
Can I take Gliclazide with Lornoxicam?
MediHelp rates the interaction as moderate. Gliclazide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. Lornoxicam is a CYP2C9 substrate, as is gliclazide, so metabolic competition is possible, and renal effects of NSAIDs may add to the risk.
How serious is the interaction between Gliclazide and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping lornoxicam and reduce the gliclazide dose if hypoglycemia occurs. Keep NSAID courses short.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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